Azumi 2, which picks up shortly after the events of the first Azumi, is set around the beginning of the Tokugawa period of Japan (1603 - 1867). In Azumi 2, the sword-wielding Azumi struggles to put to rest the threat of Tokugawa rival Masayuki Sanada in order to maintain national unity and to keep Japan on its destined course.

Azumi is based on the manga by Yuu Koyama and was originally presented in Big Comic Spirits in 1994. Since then, it has been released by Shogakukan in incrementing volumes.

Azumi II continues shortly after the end of the previous film with Aya Ueta returning in the title role of a young ninja assassin charged with keeping the nation from falling into civil war. Her main opponent is a government official named Masayuki Sanada (Mikijiro Hira) who employs a "killer ninja squad."